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• We have developed
software to generate a number of fragment-based screening libraries for
our own use. Given our internal success, we have used the
same methodology to create a series of commercial offerings.
In general, the screening libraries contain ~350 compounds and have
been optimized to cover as much diversity space as possible given
the target class restrictions. Currently we do not synthesize
these compounds but rather we extensively mine > 10 million
compounds to select the most appropriate material for our own
screens and pass this experience on to our library customers.
•
A
number of in-house computational approaches including psuedo-3D
pharmacophore mapping, Bayesian probability modeling and
bio-property prediction schemes are used during our selection
process. These may be tailored for specific target classes upon
request.
•
Compounds may be screened by common
methods such as x-ray crystallography, NMR, or SPR. Since the
fragments are selected for solubility, they may also be appropriate
for high-concentration biochemical screens and have been used
successfully for protein families such as kinases. Compounds
arrive pre-plated in 96 well plates and have been shipped
world-wide.
Please contact
Leslie Hernandez for
current pricing and discounts.
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